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These products are for laboratory research only and not intended for medical use. They must be handled by qualified professionals in controlled laboratory environments. This compound has not been evaluated by the FDA and is not approved for human or veterinary use.
MOTS-c is supplied as a lyophilized (freeze-dried) powder with a purity of ≥98% as determined by high-performance liquid chromatography (HPLC). Each vial is accompanied by a certificate of analysis confirming purity, molecular weight, and sequence identity. This product is intended for laboratory research use only.
Published preclinical studies have employed C2C12 skeletal muscle myotubes, primary hepatocytes, macrophage cell lines, and in vivo mouse models including high-fat diet and aged rodent models. These systems have been used to investigate metabolic, inflammatory, and stress-response endpoints relevant to MOTS-c biology.
No. MOTS-c supplied by this company is strictly for in vitro laboratory research and preclinical investigation. It is not approved by any regulatory authority for human or veterinary administration, and it is not intended for use as a drug, food additive, or dietary supplement.
Peer-reviewed research has associated MOTS-c with activation of AMP-activated protein kinase (AMPK) via accumulation of the endogenous metabolite AICAR through modulation of the folate-methionine cycle. Additional research has identified nuclear translocation of MOTS-c under stress conditions and interaction with nuclear transcriptional regulatory elements, suggesting roles in retrograde mitochondrial signaling.
Quality controlled from start to finish. No outsourcing.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. Supplied as a research reagent for in vitro laboratory assays only; not for human or animal use.
These references are provided for research purposes only. Citations do not imply endorsement or approval of this product for any specific application.
